More Hype Than HOPE

More hype than HOPE.

More Hype Than HOPE To the Editor: In the recently published Heart Outcomes Prevention Evaluation (HOPE study),1 treatment with the ACE inhibitor ramipril was reported to reduce cardiovascular morbidity and mortality independent of blood pressure (BP) reduction. High-risk “normotensive” (BP 140/80 mm Hg) patients (n 9541) were randomized to receive either 10 mg of ramipril or placebo in additio...

Less hype, more hope.

Screening for Ovarian Cancer-More Hype Than Hope?

Screening for ovarian cancer is reminiscent of screening for prostate cancer: Although we have tests that seem like they should work to reduce mortality (e.g., cancer antigen [CA] 125 measurement plus ultrasonography, prostate-specific antigen testing), unfortunately we are not there yet. Publication of the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)1 generated a lo...

Transdermal progesterone creams for postmenopausal women: more hype than hope?

Various claims have been made about the benefits of transdermal progesterone creams for relieving symptoms of menopause. Peer-reviewed articles have reported that the creams can raise plasma progesterone levels slightly, but have no effect on vasomotor, psychosexual or mood symptoms, bone metabolism or plasma lipid levels. Currently available progesterone creams can not be recommended for treat...

Vitamin C and Treating Coronary Artery Disease: More Hype than Hope?